解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract:BACKGROUND:During the isolation process, pancreatic islets are exposed to an environment of sterile inflammation resulting in an upregulated inflammatory state before transplantation. Toll-like receptor 4 (TLR4) has been identified as a major mediator of sterile inflammation. Therefore, we sought to determine whether e...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0000000000002287
更新日期:2018-09-01 00:00:00
abstract::Beta cell replacement has the potential to restore euglycemia in patients with insulin-dependent diabetes. Although great progress has been made in establishing allogeneic islet transplantation from deceased donors as the standard of care for those with the most labile diabetes, it is also clear that the deceased dono...
journal_title:Transplantation
pub_type: 杂志文章,评审
doi:10.1097/TP.0000000000002217
更新日期:2018-08-01 00:00:00
abstract:BACKGROUND:Carbon monoxide (CO) inhalation protects organ by reducing inflammation and cell death during transplantation processes in animal model. However, using CO in clinical transplantation is difficult due to its delivery in a controlled manner. A manganese-containing CO releasing molecules (CORM)-401 has recently...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0000000000002201
更新日期:2018-07-01 00:00:00
abstract:BACKGROUND:Solid-organ transplant recipients with pretransplant malignancies (PTM) have worse overall survival (OS) compared to recipients without history of malignancy. However, it is unknown whether the increased risk of mortality is due to recurrent cancer-related deaths. METHODS:All solid-organ transplant recipien...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0000000000002178
更新日期:2018-07-01 00:00:00
abstract:BACKGROUND:Persistent massive ascites (PMAS) longer than 14 days after living donor liver transplantation is not uncommon and associated with worse outcome. A predictive risk scoring system was constructed after analysis of recipient, graft, and surgery-related factors. METHODS:We retrospectively reviewed adult living...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0000000000002174
更新日期:2018-06-01 00:00:00
abstract:BACKGROUND:Microvascular endothelial cells (ECs) are central to an allograft's immunogenicity. Cold ischemia and reperfusion injury associated with static cold storage and warm reperfusion activates ECs and increases the immunogenicity of the allograft. After reperfusion, mitochondrial permeability transition pore (mPT...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0000000000002163
更新日期:2018-06-01 00:00:00
abstract:BACKGROUND:HLA-specific antibodies detected by solid phase assays are increasingly used to define unacceptable HLA antigen mismatches (UAM) before renal transplantation. The accuracy of this approach is unclear. METHODS:Day of transplant sera from 211 complement-dependent cytotoxicity crossmatch-negative patients were...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0000000000002129
更新日期:2018-06-01 00:00:00
abstract:BACKGROUND:Few studies have directly compared preemptive therapy (PET) and antiviral prophylaxis (AP) for prevention of cytomegalovirus (CMV) disease in CMV seropositive (R+) orthotopic liver transplant (OLT) recipients. METHODS:We prospectively assessed CMV disease and clinical outcomes among 160 consecutive R+ OLT r...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0000000000002029
更新日期:2018-04-01 00:00:00
abstract:BACKGROUND:Liver transplant (LT) for nonalcoholic steatohepatitis (NASH) related hepatocellular carcinoma (HCC) is not well characterized in the literature. The aim of the study was to examine characteristics and outcomes of patients who had LT for NASH-HCC (NASH) versus HCC from other liver diseases (non-NASH). METHO...
journal_title:Transplantation
pub_type: 杂志文章,多中心研究
doi:10.1097/TP.0000000000002043
更新日期:2018-04-01 00:00:00
abstract:BACKGROUND:In live donor liver transplantation portal flush only of the graft is done on the bench. There are no data on antegrade arterial flush along with portal flush of the graft. METHODS:Consecutive patients undergoing elective right lobe live donor liver transplantation were block-randomized to receive either po...
journal_title:Transplantation
pub_type: 杂志文章,随机对照试验
doi:10.1097/TP.0000000000002088
更新日期:2018-04-01 00:00:00
abstract:BACKGROUND:Despite effective antiviral treatment, hundreds of kidneys from deceased donors with hepatitis C virus (HCV) are discarded annually. Little is known about the determinants of willingness to accept HCV-infected kidneys among HCV-negative patients. METHODS:At 2 centers, 189 patients undergoing initial or reev...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0000000000002099
更新日期:2018-04-01 00:00:00
abstract::Short-term outcomes of solid organ transplantation have improved dramatically over the past several decades; however, long-term survival has remained static over the same period, and chronic rejection remains a major cause of graft failure. The importance of donor, or "passenger," lymphocytes to the induction of toler...
journal_title:Transplantation
pub_type: 杂志文章,评审
doi:10.1097/TP.0000000000002001
更新日期:2018-03-01 00:00:00
abstract:BACKGROUND:Early allograft dysfunction (EAD) defined by serum total bilirubin (TB) of 10 mg/dL or greater or prothrombin time-international normalized ratio (PT-INR) of 1.6 or greater on postoperative day 7 (POD 7) or aminotransferase greater than 2000 IU/L within the first week, is associated with early graft loss aft...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0000000000001959
更新日期:2018-03-01 00:00:00
abstract:BACKGROUND:Tacrolimus (TAC) is the cornerstone of immunosuppressive regimen in liver transplantation (LT). Its pharmacokinetics is characterized by a high interpatient and intrapatient variability (IPV) leading to an unpredictable dose-response relationship. The aim of our study was to evaluate the impact of TAC IPV (I...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0000000000002052
更新日期:2018-03-01 00:00:00
abstract::The mammalian target of rapamycin inhibitors (mTOR-I), drugs widely used in transplant medicine and oncology, exert their function by inhibiting a serine/threonine kinase with a pivotal role in cellular metabolism and in a wide range of eukaryotic biological/cellular functions and signaling networks. Additionally, as ...
journal_title:Transplantation
pub_type: 杂志文章,评审
doi:10.1097/TP.0000000000001806
更新日期:2018-02-01 00:00:00
abstract::Antibody-mediated injury is a major cause of allograft dysfunction and loss. Antibodies to ABH(O) blood group antigens are classic mediators of ABO-incompatible graft rejection, whereas donor-specific anti-HLA antibodies and, more recently, autoantibodies are appreciated as important contributors to allograft inflamma...
journal_title:Transplantation
pub_type: 杂志文章,评审
doi:10.1097/TP.0000000000001872
更新日期:2018-02-01 00:00:00
abstract:BACKGROUND:Although the elderly represents a rapidly growing population among transplant recipients, age-specific aspects have not been considered sufficiently in clinical trials. Moreover, age-specific effects of immunosuppressive therapies remain poorly understood. METHODS:Here, we assessed the impact of rapamycin o...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0000000000001902
更新日期:2018-01-01 00:00:00
abstract::Eradicating transplant tourism depends on complex solutions that include efforts to progress towards self-sufficiency in transplantation. Meanwhile, professionals and authorities are faced with medical, legal, and ethical problems raised by patients who return home after receiving an organ transplant abroad, particula...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0000000000001963
更新日期:2018-01-01 00:00:00
abstract:BACKGROUND:The UK Kidney Fast-Track Scheme (KFTS) was introduced in 2012 to identify kidneys at high risk of discard and to rapidly facilitate transplantation. A retrospective analysis of kidneys transplanted through the KFTS was undertaken. METHODS:UK Transplant Registry data were collected on deceased donor kidneys ...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0000000000001860
更新日期:2017-12-01 00:00:00
abstract:BACKGROUND:Insults to the airway epithelium play a key role in constrictive bronchiolitis after lung transplantation, the typical hallmark of chronic rejection. Our hypothesis is that immunosuppressives might affect airway integrity. METHODS:A biculture of human bronchial epithelial cells and lung microvascular endoth...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0000000000001809
更新日期:2017-12-01 00:00:00
abstract:BACKGROUND:When a deceased-donor kidney is offered to a waitlisted candidate, the decision to accept or decline the organ relies primarily upon a practitioner's experience and intuition. Such decisions must achieve a delicate balance between estimating the immediate benefit of transplantation and the potential for futu...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0000000000001824
更新日期:2017-12-01 00:00:00
abstract::Liver transplantation is the most effective treatment for selected patients with hepatocellular carcinoma. However, cancer recurrence, posttransplantation, remains to be the critical issue that affects the long-term outcome of hepatocellular carcinoma recipients. In addition to tumor biology itself, increasing evidenc...
journal_title:Transplantation
pub_type: 杂志文章,评审
doi:10.1097/TP.0000000000001844
更新日期:2017-11-01 00:00:00
abstract:BACKGROUND:Postoperative damage of the urethral rhabdosphincter and nerve-vascular networks is a major complication of radical prostatectomy and generally causes incontinence and/or erectile dysfunction. The human skeletal muscle-derived stem cells, which have a synchronized reconstitution capacity of muscle-nerve-bloo...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0000000000001613
更新日期:2017-10-01 00:00:00
abstract:BACKGROUND:Little is known about innate lymphoid cell (ILC) populations in the human gut, and the turnover of these cells and their subsets after transplantation has not been described. METHODS:Intestinal samples were taken from 4 isolated intestine and 3 multivisceral transplant recipients at the time of any operativ...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0000000000001593
更新日期:2017-10-01 00:00:00
abstract:BACKGROUND:Avoiding donor-specific antibody (DSA) is difficult for sensitized patients. Improved understanding of the risk of low level DSA is needed. METHODS:We retrospectively compared the outcomes of 954 patients transplanted with varied levels of baseline DSA detected by single antigen beads and B flow cytometric ...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0000000000001619
更新日期:2017-10-01 00:00:00
abstract:BACKGROUND:Mammalian target of rapamycin inhibitors may confer cardioprotective advantages, but clinical data are limited. METHODS:In the open-label ELEVATE trial, kidney transplant patients were randomized at 10 to 14 weeks after transplant to convert from calcineurin inhibitor (CNI) to everolimus or remain on standa...
journal_title:Transplantation
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1097/TP.0000000000001739
更新日期:2017-10-01 00:00:00
abstract:BACKGROUND:We herein investigate critical ischemia times and the effect of novel preservation solutions such as new histidine-tryptophan-ketoglutarate (HTK-N) and TiProtec on the individual tissues of a rat limb isograft. METHODS:Orthotopic hind-limb transplantations were performed in male Lewis rats after 2 hours, 6 ...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0000000000001845
更新日期:2017-09-01 00:00:00
abstract:BACKGROUND:Living kidney donors have donation-related out-of-pocket costs (direct costs) and/or ongoing daily expenses while losing income (indirect costs). Yet there is little information about how much of a subjective burden these constitute for the donors. METHODS:From December 2003 through December 2014, we survey...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0000000000001568
更新日期:2017-09-01 00:00:00
abstract:BACKGROUND:Infections are a major cause of morbidity and mortality in kidney allograft recipients. In this post hoc analysis of a randomized clinical trial which tested the effect of denosumab on bone mineral density, we assessed the impact of this drug on the incidence and severity of infections in the first year afte...
journal_title:Transplantation
pub_type: 杂志文章,随机对照试验
doi:10.1097/TP.0000000000001547
更新日期:2017-09-01 00:00:00
abstract::Acute rejection (AR) remains the biggest challenge during the first year after heart transplantation despite advances in immunosuppressive therapy. The early detection and curbing of AR are crucial to the survival of transplant recipients. However, as the criterion standard for AR, endomyocardial biopsy has several li...
journal_title:Transplantation
pub_type: 杂志文章,评审
doi:10.1097/TP.0000000000001780
更新日期:2017-09-01 00:00:00
abstract::HLAs are fundamental to the adaptive immune response and play critical roles in the cellular and humoral response in solid organ transplantation. The genes encoding HLA proteins are the most polymorphic within the human genome, with thousands of different allelic variants known within the population. Application of th...
journal_title:Transplantation
pub_type: 杂志文章,评审
doi:10.1097/TP.0000000000001830
更新日期:2017-09-01 00:00:00
abstract::Precision medicine is an emerging integrative approach for disease prevention, early detection, and treatment which takes into account individual variability in genetic and other molecular measurements, medical history, environmental exposures, and lifestyle. The development and availability of genomic and other molec...
journal_title:Transplantation
pub_type: 杂志文章,评审
doi:10.1097/TP.0000000000001664
更新日期:2017-08-01 00:00:00
abstract:BACKGROUND:Angiogenesis contributes to the repair process after renal ischemia/reperfusion (I/R) injury. In the present study, we tested the role of miR-21 in the angiogenesis induced by hypoxia inducible factor (HIF)-1α through inhibiting a predicted target gene thrombospondin 1 (TSP-1). METHODS:To stabilize HIF-1α, ...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0000000000001501
更新日期:2017-08-01 00:00:00
abstract:BACKGROUND:Patients with high tacrolimus clearance eliminate more drug within a dose interval compared with those with low clearance. Delays in dosing time will result in transient periods of lower concentrations in high versus low clearance patients. Transient subtherapeutic tacrolimus concentrations may induce acute ...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0000000000001796
更新日期:2017-08-01 00:00:00
abstract:BACKGROUND:MicroRNA-155 (miR-155) is known to be involved in autoimmune diseases, inflammation, and transplantation. However, its role in a warm hepatic ischemia-reperfusion (IR) model has not been fully elucidated. METHODS:Partial hepatic IR was performed in wild-type and miR-155-deficient mice treated with or withou...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0000000000001765
更新日期:2017-07-01 00:00:00
abstract:BACKGROUND:In 2013, the public health service (PHS) changed the criteria intended to identify organ donors that put the associated organ recipients at increased risk for acquiring human immunodeficiency virus (HIV), hepatitis B virus (HBV), and hepatitis C virus (HCV). The changing donor demographics, organ utilization...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0000000000001716
更新日期:2017-07-01 00:00:00
abstract:BACKGROUND:We evaluated liver transplantation waitlist and posttransplantation outcomes in those aged 18 to 24 years compared with both younger (0-17 years) and older (25-34 years) registrants and recipients. METHODS:Using national data from the United Network for Organ Sharing, competing risk, Cox regression and Kapl...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0000000000001689
更新日期:2017-07-01 00:00:00
abstract::Currently trials of immunosuppression in transplantation are in decline because their objectives remain focused on improving acute rejection rates and graft survival in the first 12 months. With 1 year renal graft survival rates of greater than 90% the best that can be hoped for is noninferiority trial outcomes compar...
journal_title:Transplantation
pub_type:
doi:10.1097/TP.0000000000001648
更新日期:2017-07-01 00:00:00
abstract:BACKGROUND:Although islet xenotransplantation is a promising therapy for type 1 diabetes, its clinical application has been hampered by cellular rejection and the requirement for high levels of immunosuppression. The aim of this study was to determine the role of Foxp3 regulatory T (Treg) cells in costimulation blockad...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0000000000001482
更新日期:2017-07-01 00:00:00
abstract:BACKGROUND:Scientific Registry of Transplant Recipients report cards of US organ transplant center performance are publicly available and used for quality oversight. Low center performance (LP) evaluations are associated with changes in practice including reduced transplant rates and increased waitlist removals. In 201...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0000000000001373
更新日期:2017-06-01 00:00:00